Aberrant planar cell polarity induced by urinary tract obstruction
نویسندگان
چکیده
منابع مشابه
Aberrant planar cell polarity induced by urinary tract obstruction.
Flow sensing by primary cilia of the epithelial cells is involved in cystogenesis in polycystic kidney disease. We investigate whether a similar mechanism applies to the pathogenesis of cyst-like tubular dilatation induced by ureteral obstruction in mice. Robust proliferation occurs in the obstructed tubules when urine flow is interrupted as well as in the repairing tubules when urine flow is r...
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Mutations in PKD1, which encodes polycystin-1 (PC1), contribute to >85% of cases of autosomal dominant polycystic kidney disease (ADPKD). The planar cell polarity (PCP) pathway is necessary for the oriented cell division and convergent extension that establishes and maintains the structure of kidney tubules, but the role of this pathway in the pathophysiology of ADPKD is incompletely understood...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2009
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00318.2009